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SMA Gold Prem 2 Catch-up Formula

For Preterm and low birthweight infants

SMA Gold Prem 2 is the only post discharge formula (PDF) in the UK to be enriched with alpha-lactalbumin (alpha-protein), which is the main protein in breast milk.  It has been specially designed to provide a nutritionally sound transition to standard term formula to meet the unique nutritional needs of preterm and LBW bottle-fed infants following discharge from hospital, until six months postnatal age. 
 

 

Specially tailored formula
For preterm and low birthweight babies up to 6 months.  The only post discharge formula to be enriched with alpha-protein.  For more information on alpha-protein click here

 

Nutritionally complete
A nutritionally complete formula with higher energy, protein, vitamins and minerals compared to typical infant milks

 

Omega 3 & 6
To help support visual acuity and brain development

 

Early arrivals have different nutritional needs on discharge from hospital

…there is considerable evidence that nutrient status has not caught up to normal at discharge even when in-hospital nutrition is managed optimally57 
 

What are the challenges for preterm/LBW infants after hospital?

  • Most have accumulated significant energy, protein, mineral and other nutrient deficits since birth58
  • Many still weigh less than term infants5,59
  • Nutrition should be carefully planned on the basis of the preterm/LBW infant’s individual needs5

 

 

What is the expert recommendation?

 

  • Preterm/LBW infants fed a PDF (n=67) were greater in length, weighed more, and had a greater head circumference than those fed a standard term formula (n=56) 60

 

  

What are the key nutrients for preterm/LBW infants after hospital?

  

  • PDFs contain more energy, protein, calcium and other nutrients than standard term formulas to help post discharge preterm/LBW infants grow and develop 58
  • SMA Gold Prem 2 provides a nutritionally sound transition to term formula. To meet the higher nutritional needs of preterm/LBW infants on discharge, it contains:

 

SMA Gold Prem 2 is the only PDF in the UK & ROI enriched with alpha-protein

 

SMA Gold Prem 2 is the only PDF in the UK & ROI enriched with alpha-protein

  •  The nutritional value of alpha-protein lies in its high proportion of essential amino acids, specifically tryptophan, cysteine and lyseine63

 SMA Gold Prem 2 is enriched with alpha-protein

  •  The predominant whey protein in breast milk 25,26
  • A source of essential amino acids – the building blocks of protein 25
  • Important for the healthy growth and repair of muscles and tissue, and for proper brain development 25
  • Increasing the alpha-protein content allows for a reduction in the beta-lactoglobulin content – a protein not naturally found in breast milk26 

 

SMA Gold Prem 2 has the lowest osmolality of post discharge formula in the UK and ROI. It is specifically formulated to help support developing body systems

 

SMA Gold Prem 2 has the lowest osmolality of post discharge formula in the UK and ROI.It is specifically formulated to help continue to help support developing body systems

  •  A blend of lactose and glucose polymers maltodextrin (glucose polymers) to help reduce osmolality and help promote gastrointestinal tolerance in infants who have difficulty digesting lactose 31,32 A low potential renal solute load (168 mOsm/L) to reduce the burden on the immature kidneys of preterm/LBW infants 18

 

What are the guidelines and recommendations to help support brain, eye and nervous system development?

 

The World Association of Perinatal Medicine (WAPM) recommends  the use of infant formulas fortified with long-chain polyunsaturated fatty acids (LCPs) 34

SMA Gold Prem 2 contains the Omega-6 LCP arachidonic acid (AA) and Omega-3 LCP docosahexaenoic acid (DHA), which have been shown to help support visual acuity and brain development. 35-37 These LCPs are in the same triglyceride form as found in breast milk 38. The LCPs are derived from a pure vegetable source that has been proven to be safe, effective and well tolerated 12,39

 

Vitamins and minerals to help support catch-up growth

 

  • SMA Gold Prem 2 is a nutrient-dense formula with appropriate levels of vitamins and minerals to help catch-up growth
  • SMA Gold Prem 2 has been carefully formulated to continue to meet the increased requirements of preterm/LBW infants. 
     

 

References

5. Casey PH. Growth of low birth weight preterm children. Semin Perin 2008; 32: 20-27.

12. Vanderhoof J et al. A multicenter long-term safety and efficacy trial of
preterm formula supplemented with long-chain polyunsaturated fatty acids. J Pediatr Gastroenterol Nutr 2000; 31(2): 121-127.

18. Klein C, ed. Nutrient requirements for preterm infant formulas. J Nutr 2002; 132(6): 1395S-1577S.

25. Lien EL. Infant formulas with increased concentrations of α-lactalbumin. Am J Clin Nutr 2003; 77(suppl): 1555S-1558S.

26. Lien EL et al. Growth and safety in term infants fed reduced-protein formula with added bovine alpha-lactalbumin. J Pediatr Gastroenterol Nutr 2004; 38:170-176.

31. Cicco R et al. Glucose polymer tolerance in premature infants. Pediatrics 1981; 67(4): 498-501.

32. Auricchio S et al. Intestinal glycosidase activities in the human embryo, fetus, and newborn. Pediatrics 1965; 35(6): 944-954.

34. Koletzko B et al. The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. J Perin
Med 2008; 36(1): 5-14.

35. Carlson SE et al. Visual-acuity development in healthy preterm infants: effect of marine-oil supplementation. Am J Clin Nutr 1993; 58(1): 35-42.

36. Hoffman DR et al. Effects of supplementation with 3 long-chain polyunsaturated fatty acids on retinal and cortical development in premature infants. Am J Clin Nutri 1993; 57(suppl): 807S-812S.

37. O’Connor DL et al. Growth and development in preterm infants fed  longchain polyunsaturated fatty acids: a prospective, randomized controlled trial. Pediatrics 2001; 108(2): 359-371.

38. Koletzko B et al. Long chain polyunsaturated fatty acids (LC-PUFA) and perinatal development. Acta Paed 2001 Apr; 90(4): 460-464. Review.

39. Vanderhoof J et al. Evaluation of a Long-Chain Polyunsaturated Fatty Acid Supplemented Formula on Growth, Tolerance, and Plasma Lipids in Preterm Infants up to 48 Weeks Postconceptional Age. J Pediatr Gastroenterol Nutr 1999; 29: 318-326.

58. Henderson G et al. Nutrient-enriched formula versus standard term  formula for preterm infants following hospital discharge. Cochrane Database of Systematic Reviews 2007; :CD004696. doi:10.1002/14651858.  D004696.pub3.

ADD REFERENCE 60 & 61

62. Bishop NJ et al. Increased bone mineral content of preterm infants fed  with a nutrient enriched formula after discharge from hospital. Arch Dis Child  1993; 68(5): 573-578.

63. Davis AM et al. alpha-lactalbumin-rich infant formula fed to healthy term infants in a multicenter study: plasma essential amino acids and gastrointestinal tolerance. Eur J Clin Nutr 2008; 62(11): 1294-1301.

64. SMA Gold Prem 2 Product Composition.

65. Cow & Gate Nutriprem 2 datacard. www.in-practice.co.uk.

5. Casey PH. Growth of low birth weight preterm children. Semin Perin 2008; 32: 20-27.

12. Vanderhoof J et al. A multicenter long-term safety and efficacy trial of
preterm formula supplemented with long-chain polyunsaturated fatty acids. J Pediatr Gastroenterol Nutr 2000; 31(2): 121-127.

18. Klein C, ed. Nutrient requirements for preterm infant formulas. J Nutr 2002; 132(6): 1395S-1577S.

25. Lien EL. Infant formulas with increased concentrations of α-lactalbumin. Am J Clin Nutr 2003; 77(suppl): 1555S-1558S.

26. Lien EL et al. Growth and safety in term infants fed reduced-protein formula with added bovine alpha-lactalbumin. J Pediatr Gastroenterol Nutr 2004; 38:170-176.

31. Cicco R et al. Glucose polymer tolerance in premature infants. Pediatrics 1981; 67(4): 498-501.

32. Auricchio S et al. Intestinal glycosidase activities in the human embryo, fetus, and newborn. Pediatrics 1965; 35(6): 944-954.

34. Koletzko B et al. The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. J Perin
Med 2008; 36(1): 5-14.

35. Carlson SE et al. Visual-acuity development in healthy preterm infants: effect of marine-oil supplementation. Am J Clin Nutr 1993; 58(1): 35-42.

36. Hoffman DR et al. Effects of supplementation with 3 long-chain polyunsaturated fatty acids on retinal and cortical development in premature infants. Am J Clin Nutri 1993; 57(suppl): 807S-812S.

37. O’Connor DL et al. Growth and development in preterm infants fed  longchain polyunsaturated fatty acids: a prospective, randomized controlled trial. Pediatrics 2001; 108(2): 359-371.

38. Koletzko B et al. Long chain polyunsaturated fatty acids (LC-PUFA) and perinatal development. Acta Paed 2001 Apr; 90(4): 460-464. Review.

39. Vanderhoof J et al. Evaluation of a Long-Chain Polyunsaturated Fatty Acid Supplemented Formula on Growth, Tolerance, and Plasma Lipids in Preterm Infants up to 48 Weeks Postconceptional Age. J Pediatr Gastroenterol Nutr 1999; 29: 318-326.

58. Henderson G et al. Nutrient-enriched formula versus standard term  formula for preterm infants following hospital discharge. Cochrane Database of Systematic Reviews 2007; :CD004696. doi:10.1002/14651858.  D004696.pub3.

ADD REFERENCE 60 & 61

62. Bishop NJ et al. Increased bone mineral content of preterm infants fed  with a nutrient enriched formula after discharge from hospital. Arch Dis Child  1993; 68(5): 573-578.

63. Davis AM et al. alpha-lactalbumin-rich infant formula fed to healthy term infants in a multicenter study: plasma essential amino acids and gastrointestinal tolerance. Eur J Clin Nutr 2008; 62(11): 1294-1301.

64. SMA Gold Prem 2 Product Composition.

65. Cow & Gate Nutriprem 2 datacard. www.in-practice.co.uk.


!

IMPORTANT NOTICE: Breast milk is best for babies. This product must be used under medical supervision. SMA Gold Prem 2 catch-up formula is a special formula for preterm and low birthweight babies who are not solely fed breast milk. It is a nutritionally complete formula for use on discharge from hospital or when a low birthweight formula is no longer appropriate. It is suitable for use as the sole source of nutrition for babies up to 6 months. Professional advice must be followed on the need for and proper method of use of SMA Gold Prem 2 and on all matters of infant feeding. SMA Gold Prem 2 is not intended for use with newborn preterm babies, for whom fortified breast milk or a low birthweight formula such as SMA Gold Prem 1 is more appropriate.

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