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SMA® ADVANCED First Infant Milk

Specially designed to help support the infants’ developing immune system1

A nutritionally complete, easy-to-digest2 infant milk suitable from birth.

The first infant formula to contain our unique clinically proven blend of 5 HMOs (2’FL, DFL, LNT, 3’SL, 6’SL)*.

Product description

SMA ADVANCED First Infant Milk 800 g Powder

Supports immune and gut health

Significant improvement in infant’s gut microbiota and positively influences the developing immune system1. Contains Zinc and vitamins A, C & D to help support the normal function of babies immune system3-5


Easy to digest

Protein broken down into smaller pieces and contains 100% whey protein for softer stools2


Suitable for C-sec babies

Shown to increase beneficial bacteria in the gut microbiome of infants born via c-section**1

Infants fed formula supplemented with 2’FL, DFL, LNT, 3’SL, 6’SL had:

  • Higher abundance of beneficial bifidobacteria, including B infantis (one of the predominant species in breastfed infants)†1
  • Lower abundance of pathogens: ~ 80% less toxigenic Clostridioides difficile, reducing a risk factor for GI infection (C difficile diarrhoea)†1
  • Higher levels of secretory immunoglobulin A (sIgA), the most abundant antibody in the gut, critical to immune health†1
  • Higher abundance of beneficial Bifidobacterium in infants born via c-section at 6 months†1
The first 1,000 days of a baby’s life have a life-long impact on many aspects of future health.

Research suggests that breastfed babies have fewer infections and may have a stronger immune system,6 which in part may be due to the presence of human milk oligosaccharides (HMOs).7-8 Click here for more information about HMOs.

The growth pattern of a breastfed baby is associated with improved health outcomes.9-11 Breastfed babies tend to grow more slowly than bottle-fed babies.9-11 Protein is one of the main drivers of growth, and the quantity and quality of protein in breast milk are ideal to support appropriate growth.

For information on suitability for use in Halal diets please contact the Careline on 0800 081 81 80 (UK) or 1800 931 832 (Ireland).

SMA® ADVANCED First Infant Milk
Shown to be safe, well-tolerated and support age-appropriate growth1, with secondary outcomes shown to support metabolic, immune and digestive health1.

SMA® ADVANCED First Infant Milk
The low protein infant formula milk in the UK & Ireland to support appropriate growth.12-19

HMO, Structurally identical Human Milk Oligosaccharides, not sourced from breast milk
*As of September 2022
**At 6 months vs control
Secondary outcome

Data card


SMA ADVANCED First Infant Milk 800 g Powder
800 g Powder

The scoop is provided under the lid. It can be stored in suspension inside the can.

Comparison charts

  SMA® ADVANCED First Infant Milk Aptamil ADVANCED First Infant Milk12-13
Contains latest breakthrough in infant nutrition - a unique 5-HMO Complex (2’FL, DFL, LNT, 6’SL and 3’SL)    
Easy-to-digest, 100% whey dominant, partially hydrolysed protein    
Low protein infant formula    
Contains DHA (Omega 3)    
Nutritionally complete    


How to open and prepare your baby's feed – powder (800 g)

While this product is made under strict hygienic conditions, it is not sterile. Failure to follow instructions on preparation and storage may make your baby ill.


Pull the safety seal and open the lid. Lift the tab, pull on the foil seal, carefully and safely remove the seal and dispose of it.


Wash hands well. Wash and sterilise all utensils according to manufacturers’ instructions.


Boil 1 litre of fresh tap water. Allow boiled water to cool for no more than 30 minutes. Do not use artificially softened or repeatedly boiled water.


Using only the scoop provided, add the correct number of scoops of powder (see feeding guide), levelling off each scoop with the back of a clean, dry knife. Store the scoop in suspension inside the can and replace lid.


Place the sterilised teat and cap on the bottle and shake well until powder is fully dissolved. Cool bottle under cold running water or in a bowl or jug of cold water until lukewarm, do not immerse the teat. Test temperature by shaking a few drops onto the inside of your wrist.

Feeding guide

Feeding guide birth – 12 months

Approx. age of baby

Approx. weight of baby

Preparation for single feeds

Feeds in 24 hours


Cooled, freshly boiled water



Level scoops


fl. oz. (approx.)

Birth – 2 weeks






2 – 4 weeks







4 – 8 weeks






2 months







3 months







4 months







6 months







7 – 12 months







This table is a guide only; a baby may need more or less than the volumes stated. Caregivers should consult their healthcare professional if more advice is needed. Remember, a baby should be fed on demand. 

Mix 1 scoop of powder to 30 ml (approx. 1 fl. oz.) of water. Approx. 181 scoops per can (applicable to 800 g can only). 1 scoop = 4.4 g.

Important feeding information

SMA® ADVANCED First Infant Milk - 800g


Do not add extra powder or water to make the feeds stronger or weaker and do not press powder into scoop. Using too much or too little powder can make your baby ill.


We recommend preparing each feed in individual bottles when required.


For hygienic reasons, discard unfinished feed in the bottle as soon as possible.


For older babies, made-up formulae can be added to food.


Do not alter or add to formulae unless medically directed.


Do not warm feeds in a microwave, hot spots may occur and cause scalding.


Remember, cows' milk should not be used as a drink during the first year.

  1. Bosheva, M., Tokodi, I., Krasnow, A., Pedersen, H. K., Lukjancenko, O., Eklund, A. C., Grathwohl, D., Sprenger, N., Berger, B., Cercamondi, C. I., & 5 HMO Study Investigator Consortium (2022). Infant Formula With a Specific Blend of Five Human Milk Oligosaccharides Drives the Gut Microbiota Development and Improves Gut Maturation Markers: A Randomized Controlled Trial. Frontiers in nutrition, 9, 920362.

  2. Czerkies LA, et al. A Pooled Analysis of Growth and Tolerance of Infants Exclusively Fed Partially Hydrolyzed Whey or Intact Protein-Based Infant Formulas. Int J Pediatr 2018; 2018: 4969576.

  3. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). (2014). Scientific Opinion on the substantiation of a health claim related to zinc and normal function of the immune system pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA Journal, 12(5), 3653.

  4. Mora J, et al. Vitamin Effects on the Immune System: Vitamins A and D Take Centre Stage Nat Rev Immunol 2008; 8(9): 685–98.

  5. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). (2015). Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA Journal, 13(11), 4298.

  6. Victora CG, et al. Lancet 2016; 387: 475–90.

  7. Kunz C. Adv Nutr 2012; 3(3): 430S–9S.

  8. Bode L. Glycobiology 2012; 22(9): 1147–62.

  9. WHO Multicentre Growth Reference Study Group. Acta Paediatr Suppl 2006; 450: 76–85.

  10. Baird J, et al. BMJ 2005; 331: 929.

  11. Kramer MS, et al. J Pediatr 2004; 145: 600–5

  12. Aptamil Advanced First Infant milk (Powder) ( (accessed October 2022).

  13. Aptamil First Infant milk (800g pack) ( (accessed October 2022).

  14. HiPP Organic First Infant Milk datacard (accessed October 2022).

  15. Cow & Gate First Infant Milk datacard (accessed October 2022).

  16. Kendamil First Infant Milk datacard (accessed October 2022).

  17. Koletzko et al Lower Protein in infant formula is associated with lower weight up to 2y: a randomized clinical trial. Am J Clin Nutr 2009; 89: 1836–45.

  18. Weber M et al Lower protein content in infant formula reduces BMI and obesity risk at school age: follow-up of a randomized trial Am J Clin Nutr 2014;99:1041–51.

  19. Kirchberg FF, Harder U, Weber M, Grote V, Demmelmair H, Peissner W, et al. Dietary protein intake affects amino acid and acylcarnitine metabolism in infants aged 6 months. J Clin Endocrinol Metab. 2015;100(1):149-58.


We believe that breastfeeding is the ideal nutritional start for babies and we fully support the World Health Organization’s recommendation of exclusive breastfeeding for the first six months of life followed by the introduction of adequate nutritious complementary foods along with continued breastfeeding up to two years of age. We also recognise that breastfeeding is not always an option for parents. We recommend that healthcare professionals inform parents about the advantages of breastfeeding. If parents choose not to breastfeed, healthcare professionals should inform parents that such a decision can be difficult to reverse and that the introduction of partial bottle-feeding will reduce the supply of breast milk. Parents should consider the social and financial implications of the use of infant formula. As babies grow at different rates, healthcare professionals should advise on the appropriate time for a baby to begin eating complementary foods. Infant formula and complementary foods should always be prepared, used and stored as instructed on the label in order to avoid risks to a baby’s health.