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SMA® ADVANCED First Infant Milk

Specially designed to help support the infants’ developing Immune system1-3

A nutritionally complete, easy-to-digest infant milk suitable from birth, it can be used for infants who are not being breastfed or who are being combination fed.

Product description


Contains Human Milk Oligosaccharides* 2’FL and LNnT

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Contains Zinc and vitamins A, C & D to help support the normal function of babies immune system1

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Easy to digest – Partially hydrolysed, 100% whey protein for softer stools4-5

Infants fed formula supplemented with 2’FL and LNnT2 had: gut microbiota composition closer to breastfed baby6 70% lower risk of parent-reported bronchitis2 (P≤0.01) 53% lower use of antibiotics2 (P<0.05)

The first 1,000 days of a baby’s life have a life-long impact on many aspects of future health.

SMA® ADVANCED First Infant Milk The 1st infant milk in the UK to contain HMOs* (2’FL & LNnT).7-17

Research suggests that breastfed babies have fewer infections and may have a stronger immune system,18 which in part may be due to the presence of human milk oligosaccharides (HMOs).19-20 Click here for more information about HMOs.

The growth pattern of a breastfed baby is associated with improved health outcomes.21-23 Breastfed babies tend to grow more slowly than bottle-fed babies.21-23 Protein is one of the main drivers of growth, and the quantity and quality of protein in breast milk are ideal to support appropriate growth.

For information on suitability for use in Halal diets please contact the Careline on 0800 081 81 80 (UK) or 1800 931 832 (Ireland).

SMA® ADVANCED First Infant Milk
Shown to be safe, well tolerated, and support age-appropriate growth,2 with secondary outcomes associated with immune support2

SMA® ADVANCED First Infant Milk
The lowest protein infant formula milk in the UK & Ireland to support appropriate growth.1–11,22

Yellow Tick

Contains 2FL & LNnT

Yellow Tick

Contains Zinc and vitamins A, C & D1

Yellow Tick

Easy to digest4-5

Secondary outcomes
*HMO, structurally identical human milk oligosaccharides, not sourced from breast milk

Data card


800 g Powder

The scoop is provided under the lid. It can be stored in suspension inside the can.

Comparison charts

A nutritionally complete, easy-to-digest infant milk suitable from birth, it can be used for infants who are not being breastfed or who are being combination fed. This formula is the 1st infant milk in the UK & Ireland to contain HMOs* (2FL & LNnT)1–11 the latest breakthrough in infant nutrition.

  SMA® ADVANCED First Infant Milk7 Aptamil ProFutura First Infant Milk10
Contains latest breakthrough in infant nutrition – HMOs (2’FL & LNnT)    
Easy-to-digest, 100% whey dominant, partially hydrolysed protein    
60:40 whey:casein ratio
Lowest protein infant formula in UK & Ireland7-17  
(1.2 g / 100 ml)
(1.3 g / 100 ml)
Contains DHA (Omega 3)    
Nutritionally complete    


How to open and prepare your baby's feed – powder (800 g)

While this product is made under strict hygienic conditions, it is not sterile. Failure to follow instructions on preparation and storage may make your baby ill.


Pull the safety seal and open the lid. The scoop is provided under the lid. Lift the tab, pull on the foil seal, carefully and safely remove the seal and dispose of it.


Wash hands well. Wash and sterilise all utensils according to manufacturers’ instructions.


Boil 1 litre of fresh tap water. Allow boiled water to cool for no more than 30 minutes. Measure the required amount of water (see feeding guide) into a sterilised bottle, carefully – the water is hot. Do not use artificially softened or repeatedly boiled water.


Using only the scoop provided, add the correct number of scoops of powder (see feeding guide), levelling off each scoop with the back of a clean, dry knife. Store the scoop in suspension inside the can and replace lid.


Place the sterilised teat and cap on the bottle and shake well until powder is fully dissolved. Cool bottle under cold running water or in a bowl or jug of cold water until lukewarm, do not immerse the teat. Test temperature by shaking a few drops onto the inside of your wrist.

Feeding guide

Feeding guide birth – 12 months

Approx. age of baby

Approx. weight of baby

Preparation for single feeds

Feeds in 24 hours


Cooled, freshly boiled water



Level scoops


fl. oz. (approx.)

Birth – 2 weeks






2 – 4 weeks







4 – 8 weeks






2 months







3 months







4 months







6 months







7 – 12 months







This table is a guide only; a baby may need more or less than the volumes stated. Caregivers should consult their healthcare professional if more advice is needed. Remember, a baby should be fed on demand. 

Mix 1 scoop of powder to 30 ml (approx. 1 fl. oz.) of water. Approx. 195 scoops per can (applicable to 800 g can only). 1 scoop = 4.1 g.

Important feeding information

SMA® ADVANCED First Infant Milk - 800g


Do not add extra powder or water to make the feeds stronger or weaker and do not press powder into scoop. Using too much or too little powder can make your baby ill.


We recommend preparing each feed in individual bottles when required.


For hygienic reasons, discard unfinished feed in the bottle as soon as possible.


For older babies, made-up formulae can be added to food.


Do not alter or add to formulae unless medically directed.


Do not warm feeds in a microwave, hot spots may occur and cause scalding.


Remember, cows' milk should not be used as a drink during the first year.

  1. Mora J, et al. Vitamin Effects on the Immune System: Vitamins A and D Take Centre Stage Nat Rev Immunol 2008; 8(9): 685–98.

  2. Puccio G, Alliet P, Cajozzo C, et al. Effects of infant formula with human milk oligosaccharides on growth and morbidity: A randomized multicenter trial. J Pediatr Gastroenterol Nutr 2017; 64: 624–31.

  3. Bode L. Human milk oligosaccharides: Every baby needs a sugar mama Glycobiology 2012;9:1147–1162.

  4. Billeaud C, et al. Gastric emptying in infants with or without gastro-oesophageal reflux according to the type of milk. Eur J Clin Nutr 1990; 44: 577–83.

  5. Czerkies LA, et al. A Pooled Analysis of Growth and Tolerance of Infants Exclusively Fed Partially Hydrolyzed Whey or Intact Protein-Based Infant Formulas. Int J Pediatr 2018; 2018: 4969576.

  6. Berger et al. Linking human milk oligosaccharides, infant fecal community types, and later risk to require antibiotics. mBio 2020. 11e03196-19

  7. SMA® ADVANCED First Infant Milk datacard (accessed November 2020).

  8. SMA® PRO First Infant Milk datacard (accessed July 2020).

  9. SMA® Organic First Infant Milk datacard (accessed July 2020).

  10. Aptamil Profutura First Infant Milk datacard (accessed July 2020).

  11. Aptamil Pronutra First Infant Milk datacard (accessed July 2020).

  12. HiPP Organic First Infant Milk datacard (accessed July 2020).

  13. Cow & Gate First Infant Milk datacard (accessed July 2020).

  14. Kendamil First Infant Milk datacard (accessed July 2020).

  15. Mamia First Infant Milk nutritional information on pack (accessed February 2018).

  16. Arla First infant Milk product information (accessed July 2020).

  17. Sainsburys Little Ones First Infant Milk nutritional information (accessed July 2020).

  18. Victora CG, et al. Lancet 2016; 387: 475–90.

  19. Kunz C. Adv Nutr 2012; 3(3): 430S–9S.

  20. Bode L. Glycobiology 2012; 22(9): 1147–62.

  21. WHO Multicentre Growth Reference Study Group. Acta Paediatr Suppl 2006; 450: 76–85.

  22. Baird J, et al. BMJ 2005; 331: 929.

  23. Kramer MS, et al. J Pediatr 2004; 145: 600–5

  24. Koletzko et al Lower Protein in infant formula is associated with lower weight up to 2y: a randomized clinical trial. Am J Clin Nutr 2009; 89: 1836–45.

  25. Weber M et al Lower protein content in infant formula reduces BMI and obesity risk at school age: follow-up of a randomized trial Am J Clin Nutr 2014;99:1041–51.

  26. Kirchberg FF, Harder U, Weber M, Grote V, Demmelmair H, Peissner W, et al. Dietary protein intake affects amino acid and acylcarnitine metabolism in infants aged 6 months. J Clin Endocrinol Metab. 2015;100(1):149-58.


The World Health Organisation (WHO) has recommended that pregnant women and new mothers be informed on the benefits and superiority of breastfeeding – in particular, the fact that it provides the best nutrition and protection from illness for babies. Mothers should be given guidance on the preparation for, and maintenance of, lactation, with special emphasis on the importance of a well-balanced diet both during pregnancy and after delivery. The unnecessary introduction of partial bottle-feeding or other foods and drinks should be discouraged since it will have a negative effect on breastfeeding. Similarly, mothers should be warned of the difficulty of reversing a decision not to breastfeed. Before advising a mother to use infant formula, she should be advised of the social and financial implications of her decision: for example, if a baby is exclusively bottle-fed, more than one can (400 g) per week will be needed, so the family circumstances and costs should be kept in mind. Mothers should be reminded that breast milk is not only the best but also the most economical food for babies. If a decision to use an infant formula is taken, it is important to give instructions on correct preparation methods, emphasizing that unboiled water, unsterilized bottles or incorrect dilution can all lead to illness.