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SMA Gold Prem 1 New Look New Recipe information
Bottle of SMA Gold Prem 1 Formula 70ml in front of a yellow background
SMA Gold Prem 1 New Look New Recipe information
Bottle of SMA Gold Prem 1 Formula 70ml in front of a yellow background

SMA Gold Prem® 1

A nutritionally complete formula for the dietary management of preterm, low birthweight infants (LBW) < 1800 g who are not solely fed breast milk in hospital.

Food for special medical purposes 

This product must be used under medical supervision

Why SMA Gold Prem® 1 Formula?

  • Formulated to specifically meet the needs of the preterm infant

    Aligned with ESPGHAN guidelines to provide optimal nutrients needed to support growth, neurodevelopment and bone health(1,2)

  • Supports digestion and feed tolerance

    Partially hydrolysed protein for improved gastrointestinal tolerance(1,3,4,5)

  • Adapted levels of protein supports age-appropriate growth and promotes protein accretion

    Contains 3.6 g protein / 100 kcal (2.9 g/100 ml), levels clinically shown to support age-appropriate growth, promoting better weight gain and protein accretion(1,6)

  • First and only preterm formula to contain 2'FL and LNnT HMOs

    Clinically shown to be safe and well tolerated(1,7,8)

Preterm infants have unique nutritional needs. In order to mimic in utero growth as closely as possible, the ESPGHAN 2022 guidelines indicate the preferred food for preterm infants is fortified human milk from the infant's own mother or, if breast milk is not available, a formula that is designed specifically for preterm infants should be used.2

Breast milk contains Human Milk Oligosaccharides (HMOs) which are complex carbohydrates that act as prebiotics. HMOs are abundant in breast milk and are important because they help the immune defenses in 4 main ways:9

  • Promote growth of beneficial bacteria
  • Prevent pathogen adhesion in the gut
  • Strengthen gut barriers function
  • Educate the developing immune system

Preterm infants are a vulnerable group of infants and those who are not able to receive breast milk may have insufficient HMO intake. Early evidence suggests HMOs may reduce morbidity and mortality in preterm infants. More recent evidence suggests that the addition of the HMOs 2'Fl and LNnT to preterm formula, supports adequate growth in preterm infants and are safe and well tolerated1,9. The HMOs used in our products are not sourced from breast milk, but are produced using a fermentation process.

Available for hospital use only:
NHS Catalogue code (UK only): ABT081
United Drug Wholesale order code (Ireland only): 12426051

Data cards

SMA Gold Prem 1 Data Card
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Product details

Product formats
Bottle of SMA Gold Prem 1 Formula 70ml on a transparent background

SMA Gold Prem® 1

70 ml Bottle

Available for hospital use only

NHS Catalogue code (UK only): ABT081

United Drug Wholesale order code (Ireland only): 12426051

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Important feeding information

SMA Gold Prem® 1 – 70 ml bottle

  • Strictly follow hospital procedures.
  • Check best before date.
  • If required to heat, stand the bottle in warm water.
  • Feed immediately after opening. For hygienic reasons, discard unfinished feed as soon as possible, and always within 1 hour.
  • After use, discard bottle, teat and remaining contents. Bottles and teats are for single use only.
  • For tube feeding, once the product is prepared it should be used within 4 hours.
  • Ensure all feeding equipment is sterilised before use.
  • For enteral use only.
  • Do not alter or add to formulae unless medically directed.
  • Do not microwave, hot spots may occur and cause scalding.
  • Do not freeze.

Nutritional requirements of low birthweight infants vary according to the age, size and clinical conditions of each infant. Enteral feeding of SMA Gold Prem® 1 should be initiated in small volumes and gradually increased as tolerated. Feeding intolerance can indicate a serious condition; at the onset of symptoms, enteral feeding rate should be slowed or discontinued until symptoms resolve. Broad ranges for recommended intake are: volume 135-200ml/kg/day, energy 115-140 (-160) kcal/kg/day, protein 3.5-4-5g/kg/day2

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Preparation

Information for you to give to parents

Preparing the baby’s feed – 70 ml bottle

Failure to follow instructions on preparation and storage may make the baby ill. 

Reject bottle if the foil under cap is missing or damaged prior to opening.

An illustration of the action of handwashing with soap, on a purple background.
1

Wash hands well.

An illustration of a baby bottle standing in water, on a purple background.
2

SMA Gold Prem® 1 can be fed at room temperature. If required to heat, stand the bottle in warm water.

An illustration of a hand screwing a teat on to a baby bottle, on a purple background.
3

Shake bottle well and remove cap and aluminium foil. Unwrap orthodontic pre-sterilised teat and holding the teat ring, screw directly onto the bottle.

Illustration of a baby bottle of milk being poured on to a wrist, on a purple background.
4

If warmed, test temperature by shaking a few drops of milk onto the inside of your wrist – milk should be lukewarm.

References
  1. Zemrani, et al. Abstract presentation. 12th International Conference on Nutrition & Growth. 2025.
  2. Embleton, N. D. et al. Enteral nutrition in preterm infants (2022): a position paper from the ESPGHAN committee on nutrition and invited experts. Journal of Pediatric Gastroenterology and Nutrition. 2023; 76 (2):248-268.
  3. Senterre T and Rigo J. Hydrolyzed Proteins in Preterm Infants. Nestle Nutr Inst Workshop Ser. 2016;86: 39-49.​
  4. Mihatsch WA et al. Hydrolysed protein accelerates the gastrointestinal transport of formula in preterm infants. Acta Paediatr 2001; 90: 196-198.
  5. Mihatsch WA et al. Hydrolyzed protein accelerates feeding advancement in very low birth weight infants. Pediatrics 2002; 110(6): 1199–1203.
  6. Cooke R et al. High protein pre-term infant formula: effect on nutrient balance, metabolic status and growth. Pediatr Res, 2006; 59(2):265-270.
  7. SMA Gold Prem® 1 data card. Available at https://www.smahcp.co.uk/formula-milk/gold-prem-1 (accessed Nov 2025)
  8. Aptamil Nutriprem 1 data card. Available at www.nutricia.co.uk/hcp/pim-products/cow-gate-nutriprem-1.html (accessed Nov 2025)
  9. Hascoet J-m et al. Use of a Liquid Supplement Containing 2 Human Milk Oligosaccharides: The First Double-Blind, Randomized, Controlled Trial in Pre-term Infants. Front Pediatr. 2022; 10:858380. doi: 10.3389/fped.2022.858380
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IMPORTANT NOTICE: 

We believe that breastfeeding is the ideal nutritional start for babies as breast milk provides a balanced diet and protection against illness for a baby. We fully support the World Health Organization’s recommendation of exclusive breastfeeding for the first six months of life followed by the introduction of adequate nutritious complementary foods along with sustained breastfeeding up to two years of age. We also recognise that breastfeeding may not be an option due to certain medical conditions. Parents should only feed Infant formula for special medical purposes under supervision of a healthcare professional after full consideration of all feeding options, including breastfeeding. Continued use must be assessed by the healthcare professional in relation to the baby's progress bearing in mind any social and financial implications for the family. Infant formula should always be prepared, used and stored as instructed on the label in order to avoid risks to a baby’s health. This product must be used under medical supervision. SMA Gold Prem® 1 is a special formula intended for the dietary management of preterm low birthweight babies who are not solely fed breast milk. It is suitable for use as the sole source of nutrition for preterm babies from birth. SMA Gold Prem® 1 is not intended for use with older preterm babies, for whom a special catch-up formula such as SMA Gold Prem® 2 is more appropriate.